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Humboldt-Universität zu Berlin - Mathematisch-Naturwissen­schaft­liche Fakultät - Kardiovaskuläre Physik

Humboldt-Universität zu Berlin | Mathematisch-Naturwissen­schaft­liche Fakultät | Institut für Physik | Kardiovaskuläre Physik | Publications | Does the Aminopeptidase A (APA) Have Prognostic and Diagnostic Value in Chagas' Disease and Other Dilated Cardiomyopathies?

Y Wang, MC Moreira, S. Heringer-Walther, A. Khan, HP Schultheiss, Niels Wessel, WE Siems, and Thomas Walther (2011)

Does the Aminopeptidase A (APA) Have Prognostic and Diagnostic Value in Chagas' Disease and Other Dilated Cardiomyopathies?

J Cardiovasc Pharmacol.

Chagas disease (CD) which is caused by the protozoan Trypanosoma cruzi is a major cause of heart failure in Latin America. We investigated if plasma activity of one of the enzymes being part of the renin-angiotensin system, aminopeptidase A (APA), has diagnostic and prognostic potency in patients with CD and dilated cardiomyopathies due to other causes (DCM). Blood samples were taken from 94 CD patients, 46 DCM patients, and 34 healthy control subjects. Plasma APA activity was determined by fluorometry assays. The average follow-up time was 39 months; by the end of study 33 patients had died and another 13 received heart transplant. There was no significant alteration in plasma APA activity in patients with CD or DCM, as compared to that in controls. The Pearson correlation of echocardiographic data with plasma APA activity in CD and DCM patients did not reveal any significant correlation with left ventricular ejection fraction or other echocardiographic parameters. APA activity was unable to predict mortality or the need for heart transplant. Detection of APA activity in plasma may not prove suitable for prognosis in patients with heart failure and is unable to screen or diagnose asymptomatic patients with CD for early therapy.